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Does anyone know the specific mechanism by which #Cannabis, and specifically #THC, #CBD, #CBN, or #CBG increase visual acuity?
Best guess is that endogenous #cannabinoids tend to regulate prefrontal cortex cAMP similar to norepinephrine and α2 agonists.
So, partial agonists like THC/CBN would have a more obvious role in causing a cascade down endocannabinoid pathways. CBD/CBG are antagonists, which suggests they may have classical reuptake inhibition properties.
And I honestly can't believe a server that WANTS to federate with Meta makes me cw that. What a load of shit 
I was talking about pharmacology, not ripping PCP and punching Kev's grandma for shits sake.
Anyway, it would certainly explain why some people with #ADHD are able to focus better when they're high. We tend to be opposite... it causes you rage? Well it makes me feel normal. It makes you paranoid and sleepy? Funny... it was the first time I had laughed in 6 years.
@AndyScott who made you CW it?
@signaleleven
I just checked the About page and the wording has changed?
> Do not post about inflammatory,
> controversial subjects without a Content
> Warning.
I remember it being a lot more strongly worded with politics, drugs, and alcohol mentioned as possible but not specific examples. I threw a shit fit one time about how selectively the rules are applied so maybe they're vague on purpose now.
Possible I'm remembering it wrong too. Eh fuck it, removed the warning. Come and get me.
@AndyScott well I read it even with the CW because I found it interesting 
@signaleleven I love this stuff. It's a puzzle I can never solve, and that makes me insane. But I love it :)
@AndyScott as a medicated ADHD person I find it interesting, but not being able to measure directly neurotransmitters in the average patient makes me wonder how much we're all flattened to the average of (hopefully great) scientific papers.
I mean, my medication works wonders, so I guess I'm somewhere in that average, but if I were to consume cannabis products I could only formulate hypothesis based on my perceptions, but couldn't measure anything. And that makes it a bit uninteresting.
@signaleleven Cannabis is tricky. Unpredictable (but not harmful), then you mix ADHD's lack of predictability (harmful), well it can go a lot of different ways.
I do the same if I don't have a plan. Lots of pondering, zero doing. Better than being stuck in a hyerfocus for me though. At least I don't feel bad. In fact, it helps me laugh at the inattentiveness. Sometimes a nice change from the flood of "WHAT'S WRONG WITH YOU" memories my mind likes to throw at me at the wrong time/all the time...
@signaleleven As for the studies... I don't trust them. Too many competing interests. The people who study THC these days are mostly either funded by the feds or by the industry.
Studies on stimulants aren't much better. Mostly done with boys, maybe girls, rarely adults, and _never_ adult women. Post-pubescent girls are also excluded (hormone fluctuations fuck with ADHD in a bad way, and we can't have their periods hurting profits).
And of course the ammosexuals don't want us to exist at all.
@signaleleven I think those meds that work so damn well are running out. One more thought - dosing for stims is based almost exclusively on children. That's where they got the weird Adderall dosing of "40 is the max, except when it isn't, then 60"
It's among the most unscientific stuff I've seen on pubmed. Unless genetic males without any other health problems between age 7 and 14 represent all of humanity, it's guesswork at best.
Sorry for the cynicism, but thanks if you made it this far ;)